Hi Brach, yes it works fine with guitar into amp input. Haven’t tried with other FX loops, so possibly something to do with my Orange Rocker 32, but it has a buffered FX loop. I notice the same when using with a preamp pedal (Kraken V4). Same thing happens to an analog Joyo EQ pedal I have, but not to my digital pedals (Strymon DIG and Nuenaber Illumine).